Finding the right antidepressant medication can be overwhelming. However, with the right information about how each works and their common side effects, the task becomes much more manageable. Cymbalta and Lexapro are two prescription medications popular for treating generalized anxiety disorder (GAD) and major depressive disorder (MDD), among other conditions.

Even though they are used to treat many of the same conditions, Cymbalta and Lexapro are in different classes of drugs, and their distinctions are essential to understand to make an informed decision with your psychiatrist or doctor.

Overview of Cymbalta  

Cymbalta (duloxetine) is in the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs work by boosting levels of serotonin and norepinephrine in the brain. These neurotransmitters help manage mood and minimize discomfort. Cymbalta treats depression, some anxiety disorders, fibromyalgia, and chronic neuropathic pain. 

“Patients who do not respond to SSRIs or who have been on SSRIs but they no longer work, the SNRI class is often the next option.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Overview of Lexapro 

Lexapro (escitalopram) is a prescription drug in a different class than Cymbalta. Selective serotonin reuptake inhibitors (SSRIs), like SNRIs, also increase serotonin levels in the brain to restore balance. They’re also thought to improve energy levels and general well-being. Lexapro is commonly used to treat symptoms of major depressive disorder and generalized anxiety disorder, among other conditions.

“SSRIs are the most commonly prescribed class of medications because they have less side effects, no food restrictions and are much safer in overdose.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Key Similarities Between Cymbalta & Lexapro

Cymbalta and Lexapro are available through your healthcare provider by prescription and are FDA-approved to treat anxiety and depression. These drugs work by altering serotonin levels in the brain to regain balance. Serotonin is an important neurotransmitter that affects mood and sleep, among other things, so increasing levels can help reduce symptoms of anxiety and depression. 

Efficacy in treating depression and anxiety

When comparing Cymbalta vs Lexapro for depression or anxiety, both are highly effective medication options for some people. Research suggests that Lexapro might be better tolerated and more effective when treating depression on a short-term plan.

Other research supports these findings, noting that Cymbalta might not be as tolerable as Lexapro. Remember that any drug’s efficacy might be better for one person than another.

Is Cymbalta or Lexapro better for anxiety?

Whether Cymbalta or Lexapro is better for — or more effective in treating — anxiety depends on several factors. Two people can react very differently to the same drug. Factors like the severity of symptoms, genetic makeup, the presence of other medical conditions, other drugs being taken simultaneously, dosage, and more all come into play with how well a medication works.  

Is Cymbalta or Lexapro better for depression?

Both drugs can be beneficial in reducing depression symptoms, but some bodies of research suggest Lexapro may have fewer side effects, making the drug more tolerable and, thus, more effective overall. Keep in mind that the path to treating depression is very individual. What works for one person may not be effective for the next. 

“The chemical structure of Lexapro is very similar to Celexa. It is considered to work just as well as Celexa but with fewer side effects and possible faster results.”

– Talkspace psychiatrist Dr. Dion Metzger, MD
Shared side effects

Similar side effects can occur when taking Cymbalta or Lexapro. Commonly shared side effects of Cymbalta and Lexapro include:

Dry mouth

Nausea

Difficulty sleeping

Diarrhea

Drowsiness 

Dizziness

Drug interactions

Drug interaction can happen with any drug combined with other medications, supplements, or vitamins. Your doctor or psychiatrist will go through your drug history and review other medications you’re taking before prescribing either Cymbalta or Lexapro to ensure your antidepressant medication is going to be safe and effective. 

Some medications to be aware of that may have an adverse interaction with Lexapro or Cymbalta include:

St. John’s wort

Aspirin

NSAIDs

Monoamine oxidase inhibitors (MAOIs)

Xanax

Tricyclic antidepressants

Buspirone

Tramadol

Tryptophan

Amphetamine

Key Differences Between Cymbalta & Lexapro

The most significant difference between Cymbalta and Lexapro is that they belong to different classes of drugs. Because Cymbalta is an SNRI, it’s approved to treat chronic pain associated with some medical conditions. Other features set these drugs apart as well. 

Mechanism of action

SNRIs work slightly differently than SSRIs. Cymbalta increases serotonin and norepinephrine levels to enhance mood, regulate anxiety, and improve attentiveness and energy while reducing pain. 

SSRIs, like Lexapro, impact serotonin levels but don’t alter norepinephrine levels. By blocking the reuptake of serotonin to increase levels in the brain, Lexapro can improve mood. 

Indications and approved uses

Cymbalta has a broader range of FDA-approved uses compared to Lexapro. In addition to treating major depressive disorder and generalized anxiety disorder (like Lexapro), Cymbalta can help with chronic pain related to conditions like fibromyalgia or diabetic peripheral neuropathy.

Specific side effects

Every drug can have adverse effects, but some might be more common with Cymbalta vs Lexapro. For instance, while sexual side effects like sexual dysfunction can occur with both drugs, it is less likely with short-term use of Cymbalta, according to some research. 

Unique to Cymbalta

More likely side effects of Cymbalta include constipation, fatigue, and increased blood pressure. 

Unique to Lexapro

Lexapro might cause side effects like agitation, blurred vision, and tremors, which may not be as likely with Cymbalta. 

While not a top side effect, weight gain from Cymbalta is also something to research and consider compared to weight gain on Lexapro.

Choosing Between Cymbalta and Lexapro

Both Cymbalta and Lexapro can be used to treat depression and anxiety. Each has potential advantages that might help you choose the best one for your symptoms. 

Lexapro:

One of the best-tolerated antidepressants

Fewer drug interactions and side effects

Cymbalta:

Helps with pain

Great option when SSRIs like Lexapro, Zoloft, Prozac, or Celexa aren’t effective

Get a Professional Evaluation with Talkspace

Finding the most effective treatment plan can be difficult, but you don’t have to do it alone. While Cymbalta and Lexapro are excellent options for treating depression, anxiety, and other mental health conditions, only you and a qualified doctor or mental health professional can decide the best drug for you. 

Talkspace psychiatry offers convenient and affordable access to online psychiatrists for a prescription. Talkspace mental health professionals take the time to understand your personal and unique needs. They’ll assess your symptoms, overall health, and lifestyle before suggesting medications. 

Talkspace doesn’t just stop at prescription drugs — our team takes care of your complete mental wellness needs by integrating psychotherapy sessions and medical treatment advice when required. Discover how Talkspace can guide you to a treatment plan tailored for you, enabling a fulfilling, healthy life without the grip of depression or anxiety.